Official AMA & CMS Billing Modifiers

Medical Coding Modifiers Directory: CPT & HCPCS Modifiers List

Explore official clinical coding guidelines, NCCI bundling implications, documentation checklists, and billing rules for all major CPT and HCPCS modifiers.

E/M Services
Modifier 25
Significant, separately identifiable E/M on procedure date.
Procedural Unbundling
Modifier 59 & X{EPSU}
Distinct procedural service & CMS anatomical X-modifiers.
Diagnostic Components
Modifier 26 & TC
Professional reading vs technical equipment splits.
Global Postoperative
Modifiers 58, 78, 79
Staged, unplanned return to OR, and unrelated surgeries.

All CPT & HCPCS Modifiers (18 Total)

Updated for CMS CY 2026 Payment Policies
18 Modifiers Documented
Modifier Name & Official Descriptor Category NCCI PTP Impact Action
25
Modifier 25 indicates that on the day a minor procedure was performed, the patient condition required a significant, separately identifiable E/M service above and beyond the usual pre-procedure and post-procedure care.
Evaluation and Management (E/M) Bypasses NCCI PTP edits with modifier indicator 1. View Guidelines →
59
Modifier 59 identifies procedures or services, other than E/M services, that are not normally reported together but are appropriate under the clinical circumstances.
Surgery / Procedural Primary unbundling modifier used to bypass NCCI PTP edits with modifier indicator 1. View Guidelines →
26
Modifier 26 indicates that only the physician professional component (interpretation and written report) is being billed, rather than technical equipment or technician costs.
Radiology / Pathology / Diagnostic Distinguishes physician professional fees from hospital facility Part A fees. View Guidelines →
TC
Modifier TC indicates that only the technical component of a diagnostic procedure (equipment, supplies, technician wages) is being billed.
Radiology / Pathology / Diagnostic Separates facility overhead from professional interpretation. View Guidelines →
22
Modifier 22 indicates that the work required to perform a service was substantially greater than typically required.
Surgery / Procedural Triggers manual payer audit and claims review for additional reimbursement consideration. View Guidelines →
50
Modifier 50 identifies bilateral procedures performed during the same operative session.
Surgery / Procedural Payment adjusted to 150% of allowable fee under standard CMS bilateral surgery payment rules. View Guidelines →
51
Modifier 51 indicates that multiple procedures, other than E/M services, were performed during the same session by the same provider.
Surgery / Procedural Applies multiple surgery reduction policy across Medicare and commercial payers. View Guidelines →
52
Modifier 52 indicates that a service or procedure was partially reduced or eliminated at physician discretion.
Surgery / Procedural Payer will typically reduce reimbursement proportionally to omitted service work. View Guidelines →
53
Modifier 53 indicates that a surgical or diagnostic procedure was terminated due to extenuating circumstances or patient safety risk.
Surgery / Procedural Carrier adjudicates claim based on documented surgical phase reached. View Guidelines →
58
Modifier 58 indicates that a procedure during a global postoperative period was planned or staged prospectively, more extensive than original procedure, or for therapy following diagnostic surgery.
Global Surgery Initiates a new global surgical period and bypasses postoperative bundling denials. View Guidelines →
76
Modifier 76 indicates that a procedure or service was repeated subsequent to the original service on the same calendar day.
Surgery / Radiology / Diagnostic Clears duplicate claim screening filters at the Medicare Administrative Contractor (MAC). View Guidelines →
77
Modifier 77 indicates that a procedure was repeated on the same day by a different physician.
Surgery / Radiology / Diagnostic Bypasses MAC automated duplicate billing filters. View Guidelines →
78
Modifier 78 indicates that an unplanned return to the operating room occurred during the global period to treat a surgical complication.
Global Surgery Reimburses the intraoperative work value (approximately 70% of surgical allowable) without paying new pre/post care. View Guidelines →
79
Modifier 79 indicates that a procedure performed during a global surgery period was completely unrelated to the original surgery.
Global Surgery Bypasses postoperative global package denials; pays 100% of standard fee schedule. View Guidelines →
XE
Modifier XE is a CMS HCPCS modifier identifying a service that is distinct because it occurred during a separate patient encounter on the same date.
CMS NCCI X-Modifiers Bypasses NCCI PTP edits with modifier indicator 1. View Guidelines →
XP
Modifier XP identifies a service that is distinct because it was performed by a different practitioner within the same group practice.
CMS NCCI X-Modifiers Bypasses NCCI PTP edits with modifier indicator 1. View Guidelines →
XS
Modifier XS identifies a service that is distinct because it was performed on a separate organ or anatomical structure.
CMS NCCI X-Modifiers Bypasses NCCI PTP edits with modifier indicator 1. View Guidelines →
XU
Modifier XU identifies a service that is distinct because it does not overlap the usual components of the primary service.
CMS NCCI X-Modifiers Bypasses NCCI PTP edits with modifier indicator 1. View Guidelines →

Pricing Modifiers vs. Informational Modifiers

Medical coding modifiers are two-character alpha, numeric, or alphanumeric codes appended to CPT or HCPCS procedure codes. They fall into two primary regulatory categories:

1. Pricing & Payment Modifiers

Directly adjust the Medicare allowable reimbursement amount or trigger fee schedule calculations. Examples include Modifier 26 (professional fee), Modifier TC (technical fee), Modifier 50 (150% bilateral adjustment), and Modifier 51 (multiple surgery reduction).

2. Informational & Statistical Modifiers

Provide crucial clinical context or establish unbundling eligibility without directly modifying the statutory conversion factor. Examples include Modifier 25 (separate E/M), Modifier 59 (distinct procedural service), and anatomical site indicators (RT, LT, E1-E4).

Top Modifier Denial Triggers on Payer Audits

The Office of Inspector General (OIG) and Comprehensive Error Rate Testing (CERT) contractors routinely target modifier overutilization. The most frequent audit triggers include:

  • Modifier 25 on Minor Procedures: Appending Modifier 25 to every routine injection, wart destruction, or biopsy when no independent evaluation of a distinct medical problem occurred.
  • Modifier 59 Overuse: Appending Modifier 59 solely to bypass claim edits without confirming separate incisions, distinct anatomical locations, or different clinical encounters.
  • Failure to Use Specific CMS X-Modifiers: Using generic Modifier 59 for Medicare claims when specific modifiers XE, XP, XS, or XU more accurately detail the service distinction.